Dynamine (Methylliberine)
Only three human RCTs have tested methylliberine. The only one measuring cognition with methylliberine alone (La Monica et al., 2023, n=25, 100mg/day) found better self-rated concentration, motivation, mood and energy, but a negligible effect on objective cognitive tests (Stroop, Trail Making B). A 4-week safety trial (VanDusseldorp et al., 2020, n=125, 100–150mg/day) found no clinically significant cardiovascular or blood changes; it did not test cognition. A third trial (Cintineo 2022) tested it only inside a caffeine + theacrine combination. Both methylliberine-specific trials were funded in whole or part by Compound Solutions, which sells Dynamine, and a La Monica co-author holds patents on methylliberine.
エビデンス確認日:
作用機序
Dynamine (methylliberine) is a purine alkaloid found in kucha tea leaves, structurally related to caffeine and theacrine. It is described as blocking adenosine receptors (like caffeine) and inhibiting phosphodiesterase. In a 4-week trial at 100–150mg/day it produced no clinically significant changes in heart rate, blood pressure or blood biomarkers. No study has measured tolerance.
臨床エビデンスの概要
Only three human RCTs have tested methylliberine. The only one measuring cognition with methylliberine alone (La Monica et al., 2023, n=25, 100mg/day) found better self-rated concentration, motivation, mood and energy, but a negligible effect on objective cognitive tests (Stroop, Trail Making B). A 4-week safety trial (VanDusseldorp et al., 2020, n=125, 100–150mg/day) found no clinically significant cardiovascular or blood changes; it did not test cognition. A third trial (Cintineo 2022) tested it only inside a caffeine + theacrine combination. Both methylliberine-specific trials were funded in whole or part by Compound Solutions, which sells Dynamine, and a La Monica co-author holds patents on methylliberine.
ヒト効果マトリクス
Based on human clinical trials only. Animal and in-vitro data excluded.
| 効果 | エビデンス | 効果の大きさ | 研究数 |
|---|---|---|---|
| Subjective Energy | preliminary | 中 | 1 |
| Focus & Motivation | mixed | 小 | 1 |
| Cardiovascular Safety | moderate | ごくわずか | 1 |
Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results
実証された効果
- Better self-rated energy, mood and motivation (one small RCT)
- No clinically significant heart rate or blood pressure change over 4 weeks at 100–150mg
副作用と注意事項
- Limited safety data: three human RCTs, both methylliberine-specific trials funded by the manufacturer
- Objective cognition: no measurable effect on Stroop or Trail Making tests in the only trial that tested it
- Mild GI discomfort possible
- Possible interaction with caffeine (additive stimulation)
- Not recommended during pregnancy (precautionary: no pregnancy data)
摂取方法
スタッキングの推奨
Dynamine (Methylliberine)と相性の良い成分とその理由。
A common pairing in pre-formulated stacks. In tactical personnel, 150mg caffeine + 100mg methylliberine + 50mg theacrine matched 300mg caffeine on vigilance reaction time with a smaller diastolic blood pressure rise (Cintineo 2022) — but that tests the combination, not Dynamine alone.
L-Theanine is commonly paired with stimulants for calmer focus, though in a controlled caffeine trial it did not significantly reduce jitteriness, and the combination with Dynamine has not been tested.
Dynamine provides acute adenosine blockade; Zynamite extends dopamine via COMT inhibition. Together found in Thesis blends for multi-pathway stimulation.
よくある質問
How is Dynamine different from caffeine?
It is a related purine alkaloid, but its evidence base is far thinner: three small human RCTs versus decades of caffeine research. In a 4-week trial at 100–150mg/day it caused no clinically significant heart rate or blood pressure change, and in the one cognition trial it improved self-rated energy and mood but not objective test performance. No trial has compared its onset, duration or sleep effects head-to-head with caffeine.
Does Dynamine build tolerance like caffeine?
Unknown. No study has measured tolerance to methylliberine; the 4-week trial measured safety markers, not whether effects fade. Claims of "minimal tolerance" are not supported by any published trial.
Can I buy Dynamine on its own?
Not easily. Dynamine (methylliberine) is a trademarked ingredient from Compound Solutions and is primarily available in pre-formulated stacks (e.g., Thesis nootropics). Standalone Dynamine capsules are rare on the consumer market.
Is it safe to combine Dynamine with caffeine?
Yes — this is a common combination in performance supplements. Since both block adenosine, the stimulant effects are additive. Keep total combined caffeine + Dynamine intake moderate and monitor for overstimulation (anxiety, restlessness). Start with low doses of each.
Dynamine (Methylliberine) in Japan
Products in Japan
None of the stacks we have audited are listed in our catalogue in Japan yet.
Consumer Affairs Agency (FFC)
Regulatory note
本ページは教育目的の編集コンテンツであり、医学的助言を構成するものではありません。日本国内で販売される機能性表示食品（FFC）および特定保健用食品（FOSHU）は、消費者庁への届出または許可を必要とします。届出のない輸入品については、日本の薬機法（旧薬事法）の下で疾病治療を示唆する表現は規制されます。サプリメントを開始する前に、必ず資格のある医療専門家にご相談ください。This page is editorial and not medical advice. Foods with Function Claims (FFC) and Foods for Specified Health Uses (FOSHU) sold in Japan require notification or approval from the Consumer Affairs Agency. Imported products without notification cannot make disease-treatment claims under the Pharmaceuticals and Medical Devices (PMD) Act. Note: In July 2026, the Consumer Affairs Agency (CAA) opened a public comment period (Notice No. 235080088, closes 30 July 2026) on proposed revisions to permitted claim wording for FFC-notified ingredients including DHA, phosphatidylserine, and NMN; compliant claim language may require updating once the final Cabinet Office Order is published. Consult a qualified healthcare professional before starting any supplement.
出典 (3)展開
- PMID 37960163Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women (2023)
- PMID 32121218Safety of Short-Term Supplementation with Methylliberine (Dynamine) Alone and in Combination with TeaCrine in Young Adults (2020)
- PMID 36016763Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial (2022)