Zynamite (Mangifera indica)
The largest and most independent trial (Dodd et al., 2024, n=114, Northumbria University with a PepsiCo co-author) gave a single 300mg dose of mango leaf extract and found no cognitive benefit — participants made more subtraction errors than on placebo. An earlier pilot (López-Ríos et al., 2020, n=16, all four authors Nektium employees) used 500mg, not 300mg, and found only a marginal reaction-time signal. Two sprint trials (2018, 2019; lead authors affiliated with Nektium, the manufacturer) combined 140mg with quercetin or luteolin and improved sprint power output, but measured no cognitive outcome. Three of the four trials are manufacturer-authored.
エビデンス確認日:
作用機序
Zynamite is a patented extract of Mangifera indica (mango leaf) standardised to >60% mangiferin. Mangiferin is a potent polyphenol that inhibits catechol-O-methyltransferase (COMT), slowing the breakdown of dopamine and norepinephrine in the prefrontal cortex. This extends the active duration of catecholamines without increasing their production — a unique mechanism distinct from precursor-loading (L-Tyrosine) or synthesis-boosting (caffeine) approaches. Additionally, mangiferin has anti-inflammatory and antioxidant properties.
臨床エビデンスの概要
The largest and most independent trial (Dodd et al., 2024, n=114, Northumbria University with a PepsiCo co-author) gave a single 300mg dose of mango leaf extract and found no cognitive benefit — participants made more subtraction errors than on placebo. An earlier pilot (López-Ríos et al., 2020, n=16, all four authors Nektium employees) used 500mg, not 300mg, and found only a marginal reaction-time signal. Two sprint trials (2018, 2019; lead authors affiliated with Nektium, the manufacturer) combined 140mg with quercetin or luteolin and improved sprint power output, but measured no cognitive outcome. Three of the four trials are manufacturer-authored.
ヒト効果マトリクス
Based on human clinical trials only. Animal and in-vitro data excluded.
| 効果 | エビデンス | 効果の大きさ | 研究数 |
|---|---|---|---|
| Reaction Time | mixed | ごくわずか | 2 |
| Sprint Power Output | preliminary | 小 | 2 |
Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results
実証された効果
- Sprint power output when combined with quercetin or luteolin (manufacturer-authored trials)
- COMT inhibition (mechanism)
副作用と注意事項
- Generally well tolerated — no serious adverse events in the four trials reviewed
- Mild GI discomfort rare
- Limited long-term safety data
- MAO inhibitors: theoretical interaction only — mangiferin inhibits COMT rather than MAO, and no clinical reports were found
摂取方法
スタッキングの推奨
Zynamite (Mangifera indica)と相性の良い成分とその理由。
Caffeine increases catecholamine release; Zynamite is proposed to slow their breakdown via COMT inhibition. The combination has not been tested in a cognitive trial.
Tyrosine provides dopamine precursor; Zynamite slows dopamine metabolism. Supply + preservation for sustained catecholamine levels.
L-Theanine smooths out any overstimulation from Zynamite's catecholamine-preserving effects. Balanced energy without agitation.
よくある質問
Is Zynamite just mango leaf extract?
Zynamite is a specific patented extract of Mangifera indica standardised to >60% mangiferin. Generic mango leaf supplements may contain far less mangiferin and are not equivalent. The sprint trials name Zynamite; the cognitive trials used mango leaf extract standardised to at least 60% mangiferin.
Is the evidence independent or manufacturer-funded?
Three of the four human trials were authored by Nektium, the manufacturer. The only trial led by an independent academic group (Dodd 2024, n=114) tested the 300mg dose and found no cognitive benefit, with more subtraction errors than placebo.
Can I take Zynamite with caffeine?
No trial has tested Zynamite with caffeine — the sports trials combined it with quercetin or luteolin. If you combine them, monitor your total stimulant load.
Zynamite (Mangifera indica) in Japan
Products in Japan
None of the stacks we have audited are listed in our catalogue in Japan yet.
Consumer Affairs Agency (FFC)
Regulatory note
本ページは教育目的の編集コンテンツであり、医学的助言を構成するものではありません。日本国内で販売される機能性表示食品（FFC）および特定保健用食品（FOSHU）は、消費者庁への届出または許可を必要とします。届出のない輸入品については、日本の薬機法（旧薬事法）の下で疾病治療を示唆する表現は規制されます。サプリメントを開始する前に、必ず資格のある医療専門家にご相談ください。This page is editorial and not medical advice. Foods with Function Claims (FFC) and Foods for Specified Health Uses (FOSHU) sold in Japan require notification or approval from the Consumer Affairs Agency. Imported products without notification cannot make disease-treatment claims under the Pharmaceuticals and Medical Devices (PMD) Act. Note: In July 2026, the Consumer Affairs Agency (CAA) opened a public comment period (Notice No. 235080088, closes 30 July 2026) on proposed revisions to permitted claim wording for FFC-notified ingredients including DHA, phosphatidylserine, and NMN; compliant claim language may require updating once the final Cabinet Office Order is published. Consult a qualified healthcare professional before starting any supplement.
出典 (4)展開
- PMID 32473365Central nervous system activities of extract Mangifera indica L. (2020)
- PMID 38665302Acute effects of mango leaf extract on cognitive function in healthy adults: a randomised, double-blind, placebo-controlled crossover study (2024)
- PMID 31661850A Single Dose of The Mango Leaf Extract Zynamite in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women (2019)
- PMID 29937737Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans (2018)