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ハーブ臨床用量 · 430–1600mg/day in trials; 800mg or less may be optimal — higher doses underperformed効果発現時間 · Acute effects within hours in single-dose trials; 4-week effects in one trial, none in a 12-week trial

Oat Straw Extract

Four small RCTs, all with manufacturer involvement: a 2011 trial (Berry et al.) in elderly people with below-average cognition found a single 1600mg dose reduced Stroop errors, but 2400mg did no better than placebo; a 2012 trial by the same group found 1500mg/day for 12 weeks had no effect on any cognitive measure in healthy older adults (material supplied by Frutarom); a 2015 trial (Kennedy et al., two Frutarom employees as co-authors) found 800mg improved speed, delayed recall and executive function in adults 40–65 with memory complaints, concluding the optimal dose is at or below 800mg; and a 2020 trial (Kennedy et al., two Anklam Extrakt employees as co-authors) found 430–1290mg improved working memory and multitasking over 4 weeks, with no effect on mood. No trial has measured cerebral blood flow.

By The Nootropic Lab editorial teamUpdated 8 min read✓ Fact-checked

エビデンス確認日:

作用機序

Oat Straw (Avena sativa) extract works primarily by inhibiting phosphodiesterase type 4 (PDE4) and monoamine oxidase B (MAO-B). PDE4 inhibition increases cyclic AMP levels in neurons, enhancing dopaminergic signalling. MAO-B inhibition slows dopamine breakdown. Additionally, oat straw increases nitric oxide production for cerebral vasodilation and contains avenanthramides — unique anti-inflammatory compounds.

臨床エビデンスの概要

Four small RCTs, all with manufacturer involvement: a 2011 trial (Berry et al.) in elderly people with below-average cognition found a single 1600mg dose reduced Stroop errors, but 2400mg did no better than placebo; a 2012 trial by the same group found 1500mg/day for 12 weeks had no effect on any cognitive measure in healthy older adults (material supplied by Frutarom); a 2015 trial (Kennedy et al., two Frutarom employees as co-authors) found 800mg improved speed, delayed recall and executive function in adults 40–65 with memory complaints, concluding the optimal dose is at or below 800mg; and a 2020 trial (Kennedy et al., two Anklam Extrakt employees as co-authors) found 430–1290mg improved working memory and multitasking over 4 weeks, with no effect on mood. No trial has measured cerebral blood flow.

ヒト効果マトリクス

Based on human clinical trials only. Animal and in-vitro data excluded.

効果エビデンス効果の大きさ研究数
Attention & Concentration mixed
小
4
Stress Response preliminary
小
1

Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results

実証された効果

  • Acute attention and executive-function gains in small trials
  • Working memory and multitasking over 4 weeks (one trial)

副作用と注意事項

  • Generally well tolerated — no serious adverse events and no blood-pressure changes in the trials reviewed
  • Mild GI discomfort rare
  • Oats are often cross-contaminated with gluten during processing — choose a certified gluten-free product if you have celiac disease

摂取方法

Dosage430–1600mg/day of green oat extract; the dose-response is non-monotonic, and one trial found the optimal dose at or below 800mg
TimingMorning or before cognitive tasks. Single-dose trials tested effects over the following hours.
With foodCan be taken with or without food. No significant absorption difference.
FormsCapsule or powder. Look for "green oat" or "Avena sativa" extract standardised to avenanthramides. Raw oat straw tea is not equivalent — the concentration is too low.

スタッキングの推奨

Oat Straw Extractと相性の良い成分とその理由。

Alpha-GPC

Oat Straw supports dopaminergic signalling via MAO-B; Alpha-GPC supports cholinergic signalling. Complementary neurotransmitter coverage for focus.

L-Tyrosine

Both support dopamine availability — Oat Straw by slowing breakdown (MAO-B), Tyrosine by providing precursor. Synergistic under stress.

Bacopa Monnieri

Oat Straw provides acute attention benefits; Bacopa provides long-term memory consolidation. Covers both short-term and long-term cognitive needs.

よくある質問

Is Oat Straw the same as oatmeal?

No. Oat Straw extract comes from the green, unripe aerial parts of Avena sativa — harvested before the oat grain matures. The active compounds (avenanthramides, saponins) are concentrated in the green straw, not the grain. Eating oatmeal does not provide nootropic effects.

Is a higher dose better?

Not in the trials. In Berry 2011, 1600mg reduced Stroop errors but 2400mg did no better than placebo, and Kennedy 2015 concluded the optimal dose was at or below 800mg. Doses of 430–1290mg worked over 4 weeks in Kennedy 2020.

Does Oat Straw contain gluten?

Oats are technically gluten-free but are commonly cross-contaminated with wheat during processing. If you have celiac disease or severe gluten sensitivity, verify the supplement is certified gluten-free or avoid it entirely.

How does it compare to caffeine for focus?

It is not a stimulant, and no trial has compared the two. The oat extract trials found small attention and working-memory gains without the typical stimulant side effects, but the evidence base is four small, manufacturer-linked trials — far thinner than caffeine's.

Oat Straw Extract in Japan

Products in Japan

None of the stacks we have audited are listed in our catalogue in Japan yet.

Consumer Affairs Agency (FFC)

Prefecture guides

Regulatory note

本ページは教育目的の編集コンテンツであり、医学的助言を構成するものではありません。日本国内で販売される機能性表示食品（FFC）および特定保健用食品（FOSHU）は、消費者庁への届出または許可を必要とします。届出のない輸入品については、日本の薬機法（旧薬事法）の下で疾病治療を示唆する表現は規制されます。サプリメントを開始する前に、必ず資格のある医療専門家にご相談ください。This page is editorial and not medical advice. Foods with Function Claims (FFC) and Foods for Specified Health Uses (FOSHU) sold in Japan require notification or approval from the Consumer Affairs Agency. Imported products without notification cannot make disease-treatment claims under the Pharmaceuticals and Medical Devices (PMD) Act. Note: In July 2026, the Consumer Affairs Agency (CAA) opened a public comment period (Notice No. 235080088, closes 30 July 2026) on proposed revisions to permitted claim wording for FFC-notified ingredients including DHA, phosphatidylserine, and NMN; compliant claim language may require updating once the final Cabinet Office Order is published. Consult a qualified healthcare professional before starting any supplement.

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